Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations

著者: C. Lorena Manzanares‐Palenzuela, Amir Masoud Pourrahimi, Jesús González‐Julián, Zdeněk Sofer, Martin Pykal, Michal Otyepka, Martin Pumera - Chemical Science 2019 被引用: 89

with fluorophore-tagged DNA by fluorescence measurements and molecular dynamics simulations. The system showed potential for biosensing with unequivocal detection at picomole levels and single-base discrimination. We found that this material possesses a kinetically unique entrapment/release behavior, with potential implications in time-controlled biomolecule delivery. Our findings present MXenes as platforms for binding nucleic acids, contributing to their potential for hybridization-based biosensing and related bio-applications.