Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women

著者: Nichole R. Klatt, Ryan K. Cheu, Kenzie Birse, Alexander S. Zevin, Michelle Perner, Laura Noël‐Romas, Anneke Grobler, Garrett Westmacott, Irene Y. Xie, Jennifer Butler, Leila E. Mansoor, Lyle R. McKinnon, Jo‐Ann S. Passmore, Quarraisha Abdool Karim, Salim S. Abdool Karim, Adam Burgener - Science 2017 被引用: 416

and other anaerobic bacteria, which depleted tenofovir by metabolism more rapidly than target cells convert to pharmacologically active drug. This study provides evidence linking vaginal bacteria to microbicide efficacy through tenofovir depletion via bacterial metabolism.