miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes

著者: Changgeng Peng, Lili Li, Ming-Dong Zhang, Carolina Bengtsson Gonzales, Marc Parisien, Inna Belfer, Dmitry Usoskin, Hind Abdo, Alessandro Furlan, Martin Häring, François Lallemend, Tibor Harkany, Luda Diatchenko, Tomas Hökfelt, Jens Hjerling‐Leffler, Patrik Ernfors - Science 2017 被引用: 145

light-touch mechanoreceptors. These light-touch-sensitive neurons, which normally do not elicit pain, produce pain during neuropathy that is reversed by gabapentin. Thus, a single microRNA cluster continuously scales acute noxious mechanical sensitivity in nociceptive neurons and suppresses neuropathic pain transduction in a specific, light-touch-sensitive neuronal type recruited during mechanical allodynia.