Biogenesis of the SpaciousCoxiella-Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3

著者: Bhavna Padmanabhan, Laura F. Fielden, Abderrahman Hachani, Patrice Newton, David R. Thomas, Hyun‐Jung Cho, Chen Ai Khoo, Diana Stojanovski, Craig R. Roy, Nichollas E. Scott, Hayley J. Newton - Infection and Immunity 2019 被引用: 25

Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates inside the lysosome-derived Coxiella -containing vacuole (CCV). To establish this unique niche, C. burnetii requires the Dot/Icm type IV secretion system (T4SS) to translocate a cohort of effector proteins into the host cell, which modulate multiple cellular processes.