Migratory CD11b + conventional dendritic cells induce T follicular helper cell–dependent antibody responses

著者: Jayendra Kumar Krishnaswamy, Uthaman Gowthaman, Biyan Zhang, Johan Mattsson, Louis Szeponik, Dong Liu, Renee Wu, Theresa White, Samuele Calabrό, Lan Xu, Magalie A. Collet, Marina Yurieva, Samuel Alsén, Per Fogelstrand, Anne Walter, William R. Heath, Scott N. Mueller, Ulf Yrlid, Adam Williams, Stephanie C. Eisenbarth - Science Immunology 2017 被引用: 232

mice did not. Loss of cDC2-dependent Tfh cell priming impaired antibody-mediated protection from live influenza virus challenge. We show that migratory cDC2s uniquely carry antigen into the subanatomic regions of the lymph node where Tfh cell priming occurs-the T-B border. This work identifies the DC subset responsible for Tfh cell-dependent antibody responses, particularly when antigen dose is limiting or is encountered at a mucosal site, which could ultimately inform the formulation and delivery of vaccines.