Activin type II receptor signaling in cardiac aging and heart failure

著者: Jason D. Roh, Ryan Hobson, Vinita Chaudhari, Pablo Quintero, Ashish Yeri, Mark D. Benson, Chunyang Xiao, Daniel A. Zlotoff, Vassilios J. Bezzerides, Nicholas Houstis, Colin Platt, Federico Damilano, Brian R. Lindman, Sammy Elmariah, Michael Biersmith, Se‐Jin Lee, Christine E. Seidman, Jonathan G. Seidman, Robert E. Gerszten, Estelle Lach‐Trifilieff, David J. Glass, Anthony Rosenzweig - Science Translational Medicine 2019 被引用: 147

ATPase (SERCA2a), a critical determinant of cardiomyocyte function. Together, our findings suggest that increased activin/ActRII signaling links aging and HF pathobiology and that targeted inhibition of this catabolic pathway holds promise as a therapeutic strategy for multiple forms of HF.