Identification of Biomarkers for Differentiation of Hypervirulent Klebsiella pneumoniae from Classical K. pneumoniae

著者: Thomas A. Russo, Ruth Olson, Chi‐Tai Fang, Nicole Stoesser, Mark A. Miller, Ulrike MacDonald, Alan D. Hutson, Jason Barker, Ricardo M. La Hoz, James R. Johnson, Martín Bäcker, Rajinder Bajwa, Andrew Catanzaro, Derrick W. Crook, Kleper de Almeda, Joshua Fierer, David E. Greenberg, Michael Klevay, Payal Patel, Adam J. Ratner, Jann‐Tay Wang, Jarosław Żola - Journal of Clinical Microbiology 2018 被引用: 759

were all associated with a hazard ratio of >25 for severe illness or death, additionally supporting their utility for identifying hvKp strains. Quantitative siderophore production of ≥30 μg/ml also strongly predicted strains as members of the hvKp-rich cohort (accuracy, 0.96) and exhibited a hazard ratio of 31.7 for severe illness or death. The string test, a widely used marker for hvKp strains, performed less well, achieving an accuracy of only 0.90. Last, using the most accurate biomarkers to define hvKp, prevalence studies were performed on two Western strain collections. These data strongly support the utility of several laboratory markers for identifying hvKp strains with a high degree of accuracy.