ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma

著者: Bo Han, Xiangqi Meng, Pengfei Wu, Ziwei Li, Siyi Li, Yangong Zhang, Caijun Zha, Qile Ye, Chuanlu Jiang, Jinquan Cai, Tao Jiang - Theranostics 2020 被引用: 123

: The present study further illustrated the novel mechanism of the ATRX/PARP1 axis contributing to TMZ resistance. Our results provided substantial new evidence that PARP inhibitor might be a potential adjuvant agent in overcoming ATRX mediated TMZ resistance in glioma.