Dietary Fructose Alters the Composition, Localization, and Metabolism of Gut Microbiota in Association With Worsening Colitis

著者: David C. Montrose, Ryohei Nishiguchi, Srijani Basu, Hannah A Staab, Xi Kathy Zhou, Hanhan Wang, Lingsong Meng, Melanie Johncilla, Juan R. Cubillos‐Ruiz, Diana K. Morales, Martin T. Wells, Kenneth W. Simpson, Shiying Zhang, Belgin Dogan, Chen Jiao, Zhangjun Fei, Akihiko Oka, Jeremy Herzog, R. Balfour Sartor, Andrew J. Dannenberg - Cellular and Molecular Gastroenterology and Hepatology 2020 被引用: 102

BACKGROUND & AIMS: The incidence of inflammatory bowel diseases has increased over the last half century, suggesting a role for dietary factors. Fructose consumption has increased in recent years. Recently, a high fructose diet (HFrD) was shown to enhance dextran sodium sulfate (DSS)-induced colitis in mice. The primary objectives of the current study were to elucidate the mechanism(s) underlying the pro-colitic effects of dietary fructose and to determine whether this effect occurs in both microbially driven and genetic models of colitis. METHODS: mice, respectively. RESULTS: mice and mice infected with C rodentium. CONCLUSIONS: Excess dietary fructose consumption has a pro-colitic effect that can be explained by changes in the composition, distribution, and metabolic function of resident enteric microbiota.