Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly

著者: Florian Zink, Simon Stacey, Gudmundur L. Norddahl, Michael L. Frigge, Ólafur Þ. Magnússon, Ingileif Jónsdóttir, Thorgeir E. Thorgeirsson, Ásgeir Sigurðsson, Sigurjón A. Guðjónsson, Jūlı́us Guðmundsson, Jón G. Jónasson, Laufey Tryggvadóttír, Þorvaldur Jónsson, Agnar Helgason, Arnaldur Gylfason, Patrick Sulem, Þórunn Rafnar, Unnur Þorsteinsdóttir, Daníel F. Guðbjartsson, Gísli Másson, Augustine Kong, Kāri Stefánsson - Blood 2017 被引用: 789

Key Points Whole-genome sequencing of 11 262 Icelanders reveals that clonal hematopoiesis is very common in the elderly. Somatic mutation of some genes is strongly associated with clonal hematopoiesis, but in most cases, no driver mutations were evident.