Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder

著者: Liping Hou, Sarah E. Bergen, Nirmala Akula, Jie Song, Christina M. Hultman, Mikael Landén, Mazda Adli, Martin Alda, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Judith A. Badner, Thomas B. Barrett, Michael Bauer, Bernhard T. Baune, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Wade H. Berrettini, Abesh Kumar Bhattacharjee, Joanna M. Biernacka, Armin Birner, Cinnamon S. Bloss, Clara Brichant‐Petitjean, Elise T. Bui, William Byerley, Pablo Cervantes, Caterina Chillotti, Sven Cichon, Francesc Colom, William Coryell, David W. Craig, Cristiana Cruceanu, Piotr M. Czerski, Tony Davis, Alexandre Dayer, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Howard J. Edenberg, Bruno Étain, Peter Falkai, Tatiana Foroud, Andreas J. Forstner, Louise Frisén, Mark A. Frye, Janice M. Fullerton, Sébastien Gard, Julie Garnham, Elliot S. Gershon, Fernando S. Goes, Tiffany A. Greenwood, Maria Grigoroiu‐Serbânescu, Joanna Hauser, Urs Heilbronner, Stefanie Heilmann‐Heimbach, Stefan Herms, Maria Hipolito, Shashi Hitturlingappa, Per Hoffmann, Andrea Hofmann, Stéphane Jamain, Esther Jiménez, Jean‐Pierre Kahn, Layla Kassem, John R. Kelsoe, Sarah Kittel‐Schneider, Sebastian Kliwicki, Daniel L. Koller, Barbara König, Nina Lackner, Gonzalo Laje, Maren Lang, Catharina Lavebratt, William Lawson, Marion Leboyer, Susan G. Leckband, Chunyu Liu, Anna Maaser, Pamela B. Mahon, Wolfgang Maier, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan L. McElroy, Melvin G. McInnis, R. Anne McKinney, Philip B. Mitchell, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Thomas W. Mühleisen, Caroline M. Nievergelt, Markus M. Nöthen, Tomáš Novák, John I. Nürnberger, Evaristus Nwulia, Urban Ösby, Andrea Pfennig, James B. Potash, Peter Propping, Andreas Reif, Eva Z. Reininghaus, John P. Rice, Marcella Rietschel, Guy A. Rouleau, Janusz Rybakowski, Martin Schalling, William A. Scheftner, Peter R. Schofield, Nicholas J. Schork, Thomas G. Schulze, Johannes Schumacher, Barbara Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Christian Simhandl, Claire Slaney, Erin N. Smith, Alessio Squassina, Thomas Stamm, Pavla Stopková, Fabian Streit, Jana Strohmaier, Szabolcs Szelinger, Sarah K. Tighe, Alfonso Tortorella, Gustavo Turecki, Eduard Vieta, Julia Volkert, Stephanie H. Witt, A. Jordan Wright, Peter P. Zandi, Peng Zhang, Sebastian Zöllner, Francis J. McMahon - Human Molecular Genetics 2016 被引用: 237

; OR = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.