Rhamnolipids and lactonic sophorolipids: natural antimicrobial surfactants for oral hygiene

著者: Mohamed S. Elshikh, Ignacio Moya‐Ramírez, Helena Moens, Sophie Roelants, Wim Soetaert, Roger Marchant, İbrahim M. Banat - Journal of Applied Microbiology 2017 被引用: 103

AIMS: To assess the efficacy of rhamnolipid (mixture of monorhamnolipid and dirhamnolipid congeners), purified monorhamnolipid, dirhamnolipid and lactonic sophorolipid biosurfactants against pathogens important for oral hygiene. METHODS AND RESULTS: against Streptococcus mutans, Streptococcus oralis, Actinomyces naeslundii, Neisseria mucosa and Streptococcus sanguinis. Combining these biosurfactants with standard antimicrobial agents namely chlorhexidine, sodium lauryl sulphate, tetracycline HCl and ciprofloxacin showed a dramatic drop in the MIC values. In addition, in vitro studies demonstrated the biosurfactants' ability to prevent and disrupt oral pathogens biofilms. The increased permeability of microorganisms treated with biosurfactant, as shown using bisbenzimide dye, in part explains the inhibition effect. CONCLUSION: The results demonstrate that rhamnolipids and LSLs have the ability to inhibit oral pathogens both in planktonic and oral biofilm states. SIGNIFICANCE AND IMPACT OF THE STUDY: The findings indicate the potential value of biosurfactants for both oral hygiene and the pharmaceutical industries since there is a serious need to reduce the reliance on synthetic antimicrobials and antibiotics.