Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer

著者: Hui Luo, Qi Zhao, Wei Wei, Lianghong Zheng, Shaohua Yi, Gen Li, Wenqiu Wang, Hui Sheng, Heng‐Ying Pu, Hai‐Yu Mo, Zhixiang Zuo, Zexian Liu, Chaofeng Li, Chuanbo Xie, Zhao-Lei Zeng, Weimin Li, Xiaoke Hao, Yuying Liu, Su‐Mei Cao, Wanli Liu, Sarah Gibson, Kang Zhang, Guoliang Xu, Rui‐Hua Xu - Science Translational Medicine 2020 被引用: 443

= 0.011 in validation cohort). Last, we found that a single ctDNA methylation marker, cg10673833, could yield high sensitivity (89.7%) and specificity (86.8%) for detection of CRC and precancerous lesions in a high-risk population of 1493 participants in a prospective cohort study. Together, our findings showed the value of ctDNA methylation markers in the diagnosis, surveillance, and prognosis of CRC.