Intracerebral hemorrhage location and outcome among INTERACT2 participants

著者: Candice Delcourt, Shoichiro Sato, Shihong Zhang, Else Charlotte Sandset, Danni Zheng, Xiaoying Chen, Maree L. Hackett, Hisatomi Arima, Jun Hata, Emma Heeley, Rustam Al‐Shahi Salman, Thompson Robinson, Leo Davies, Pablo M. Lavados, Richard I. Lindley, Christian Stapf, John Chalmers, Craig S. Anderson, For the INTERACT2 Investigators, INTERACT2 Investigators, C.S. Anderson, J. Chalmers, H. Arima, S. Davis, Emma Heeley, Y. Huang, Pablo M. Lavados, Bruce Neal, Mark Parsons, R. Lindley, Lewis B. Morgenstern, Thompson Robinson, C. Stapf, Christophe Tzourio, J.G. Wang, Yining Huang, S. Chen, X.Y. Chen, Li Cui, Z. Liu, Cheng‐Kai Lu, J. Wang, Shuo Wu, En Xu, Q. Yang, C. Zhang, J. Zhang, R. Beer, Erich Schmutzhard, P. Redondo, Markku Kaste, Lauri Soinne, Turgut Tatlisumak, C. Stapf, Katja E. Wartenberg, Stefano Ricci, K. Klijn, Elsa Azevedo, Ángel Chamorro, Marilyn Arnold, Urs Fischer, Sanjiv Kaul, Jeyaraj Pandian, H. Boyini, Sally Singh, A.A. Rabinstein, Conrado J. Estol, G. Silva, Pablo M. Lavados, Verónica V. Olavarría, Thompson Robinson, R. John Simes, M.-G. Bousser, Graeme J. Hankey, Konrad Jamrozik, S.C. Johnston, Shiyong Li, E. Heeley, C.S. Anderson, K. Bailey, J. Chalmers, Johnny T. K. Cheung, C. Delcourt, S. Chintapatla, Éric Ducasse, T. Erho, Jun Hata, B. Holder, E. Knight, Richard I. Lindley, Michele LeRoux, T. Sassé, E. Odgers, R. Walsh, Z. Wolfowicz, C.S. Anderson, G. Chen, C. Delcourt, Stephanie Fuentes, R. Lindley, Bin Peng, H Schneble, M.-X. Wang, H. Arima, Laurent Billot, Stéphane Héritier, Q. Li, Mark Woodward, C. Delcourt, Ṣẹ̀yẹ Abímbọ́lá, Simon Anderson, E. Chan, Gang Cheng, P. Chmielnik, Jun Hata, S. Leighton, J.-Y. Liu, Bodil Steen Rasmussen, Anitá Saxena, Sudeshna Tripathy, M. Armenis, M. A. Baig, B. Naidu, G. Starzec, S. Steley, C.S. Anderson, E. Heeley, Michele LeRoux, C. Delcourt, T. Sassé, E. Knight, K. Bailey, Johnny T. K. Cheung, E. Odgers, Éric Ducasse, B. Holder, Z. Wolfowicz, R. Walsh, S. Chintapatla, T. Erho, Conrado J. Estol, Anna Moles, A. Ruiz, Martina Zimmermann, J. Marinho, S. Alves, R. Angelim, Juliana Tavares de Araújo, L. Kawakami, Pablo M. Lavados, V.V. Olavarria, C. Bustos, Fernando Rodríguez González, P. Munoz, Y. Huang, X. Chen, Y. Huang, Ran Jia, Nan Li, Shanshan Qu, Y. Shu, Alexandra Song, Jianbin Sun, Jiayu Xiao, Yang Zhao, J.G. Wang, Qiu-Sha Huang, C. Stapf, Éric Vicaut, A. Chamam, M.-C. Viaud, C. Dert, U. Fiedler, V. Jovis, S. Kabla, Serge Marchand, Alfonso de la Peña, V. Rochaud, K. Mallikarjuna, H. Boyini, N. Hasan, Eivind Berge, Else Charlotte Sandset, A. S. Forårsveen, Thompson Robinson, D. Richardson, T. Kumar, Shlomo Lewin, Neil Poulter, John K. Field, Ayesha Anjum, A. Wilson, H. Perelmuter, A.M. Agarie, Andrés Barboza, Luciano Recchia, I.F. Miranda, S.G. Rauek, R. Duplessis, HM Dewey, Laura Walker, S. Petrolo, C. Bladin, Jonathon Sturm, Denis Crimmins, Denise Griffiths, Alexander Schütz, V. Zenteno, Mark Parsons, Ferdinand Miteff, Neil J. Spratt, E. Kerr, Christopher Levi, Thanh G. Phan, Henry Ma, L. Sanders, Chris Moran, Kam Cheong Wong, Stephen Read, Robin Henderson, Aaron Wong, R. Hull, G. Skinner, S. Davis, Peter J. Hand, Brian Yan, H. Tu, Benjamin R. Campbell, C.S. Anderson, C. Delcourt, David Blacker, Tissa Wijeratne, Manoji Pathirage, M. Jasinararchchi, Zelko Matkovic, Sherisse Celestino, F. Gruber, Milan R. Voško, E. Diabl, S. Rathmaier, R. Beer, Erich Schmutzhard, Bettina Pfausler, Raimund Helbok, Franz Fazekas, Urs Fischer, Birgit Poltrum, B. Zechner, U. Trummer, Matthieu Pierre Rutgers, André Peeters, Anne Dusart, Mehmet Duray, C. Parmentier, S. Ferrao-Santos, Raf Brouns, Sylvie De Raedt, Ann De Smedt, R.-J. VanHooff, Jacques De Keyser, Sheila Cristina Ouriques Martins, A.G. de Almeida, R. Broudani, N.F. Titton, Gabriel R. de Freitas, F.M. Cardoso, Louise Giesel, Natália Almeida Lima, A.C. Ferraz de Almeida, Régis Gomes, T.S. Borges dos Santos, E.M. Veloso Soares, Osório Lopes Abath Neto, G.S. Silva, D. Gomes, F.A. de Carvalho, M. Miranda, A. Marques, Viviane Flumignan Zétola, G. de Matia, Marcos Christiano Lange, Jacqueline Montes, A. Reccius, Paula Muñoz Venturelli, V.V. Olavarria, Ana Belén García Soto, R. Rivas, C Klapp, Sergio Illanes, Carlos Aguilera, A. Castro, C. Figueroa, Jhonattan Benavides, P. Salamanca, Mauricio Concha, J. Pajarito, P. Araya, Federico Guerra, Yan Li, G. Liu, B. Wang, J. Zhang, Yong Chong, Mosso He, L. Wang, J. Liu, X. Zhang, Chung‐Yu Lai, He Jiang, Qing Yang, Sophia Cui, Q. Tao, Y. Zhang, S. Yao, Ming Xu, Y. Zhang, Z. Liu, Han Xiao, Jin Hu, Jessica Tang, Jianbin Sun, H. Ji, M. Jiang, F. Yu, Y. Zhang, Xiangdong Yang, Xiaohong Guo, Y. Wang, Longfei Wu, Z. Liu, Y. Gao, Dong Sun, Xiaoting Huang, Y. Wang, L. Liu, Yan Li, Ping Li, Yi Jiang, Hezong Li, Hung‐I Lu, Junshan Zhou, C. Yuan, Xun Qi, Feng Qiu, Haiyan Qian, Weixu Wang, J. Liu, Yining Huang, Wen Sun, Fei Li, R. Liu, Qiang Peng, Z. Ren, Chao Fan, Y. Zhang, Hui‐Tian Wang, T. Wang, Fu‐Dong Shi, Chen Duan, S. Chen, J. Wang, Z. Chen, Xuerui Tan, Z. Zhao, Y. Gao, J. Chen, Tao Han, Shuo Wu, Lixin Zhang, Longsheng Wang, Qing Hu, Qing Hou, Xin Zhao, Longsheng Wang, Gaoming Zeng, Lu Ma, F. Wang, S. Chen, Li Zeng, Zhigang Guo, Yu Fu, Yang Song, L. Tai, X. Liu, X. Su, Jean Yang, Rong Dong, Yiting Xu, Sai Tian, Shasha Cheng, Li Su, Xuewei Xie, Tan Xu, Deqin Geng, Xiao Yan, Huimin Fan, Naisi Zhao, Shuguang Wang, Jean Yang, J. Zhang, Min Yan, Linxin Li, Z. Li, Xiao Yun Xu, F. Wang, Longfei Wu, Xiaohong Guo, Ying Lian, H. Sun, D. Liu, N. Wang, Q. Tang, Zhi‐Yan Han, L. Feng, Y. Cui, Jiwei Tian, Hsing‐Yi Chang, Xiangying Sun, J. Wang, Chao Liu, Z. Wen, En Xu, Q. Lin, X. Zhang, Lina Sun, Bo Hu, Mengchen Zou, Qiligeer Bao, X. Lin, Liming Zhao, X. Tian, Hui‐Tian Wang, X. Wang, Xianchan Li, Li-dan Hao, Yunyou Duan, R. Wang, Zilong Wei, J. Liu, Shuxun Ren, Hongqi Ren, Yi Wang, Yan Dong, Yali Cheng, Mengchen Zou, Wei Wei Liu, J. Han, C. Zhang, Zheng Zhang, J. Zhu, Yi Wang, Q. Li, Jun Qian, Yingxian Sun, Kuo Liu, F. Long, Xiaofei Peng, Qilu Zhang, Zong-Li Yuan, Chun Wang, Minqiang Huang, J. Zhang, F. Wang, Panpan He, Yeon Ho You, X. Wang, Q. Yang, Hui‐Tian Wang, Jun Xia, L. Zhou, Yinglong Hou, Y. Wang, L. Liu, Yunjing Qi, Ling Mei, R. Lu, G. Chen, L. Liu, L. Ping, Wei Wei Liu, Shuyu Zhou, J. Wang, L. Wang, Hezong Li, S. Zhang, Longsheng Wang, Runmei Zou, Jiang Guo, M. Li, W. Wei, Lauri Soinne, Sami Curtze, Maria Saarela, Daniel Strbian, Filip Scheperjans, T. de Broucker, Christopher Henry, R. Cumurciuc, N. Ibos-Augé, Anne-Céline Zeghoudi, Francisco Picó, Olivier Dereeper, Marina Simian, Clément Boisselier, A. Mahfoud, Serge Timsit, F.-M. Merrien, B. Guillon, M. Sevin, Fanny Hérisson, C. Magne, Abdol A. Ameri, C. Cret, S. Stefanizzi, F. Klapzcynski, Christian Denier, Mariana Sarov-Rivière, C. Stapf, Peggy Reiner, Jérôme Mawet, Dominique Hervé, F. Buffon, Emmanuel Touzé, V. Domigo, Chantal Lamy, D. Calvet, M. Pasquini, Sonia Alamowitch, Pascal Favrole, I.-P. Muresan, Sophie Crozier, Charlotte Rosso, C. Pirès, Anne Léger, S. Deltour, Charlotte Cordonnier, Hilde Hénon, Costanza Rossi, Mohammad Zuber, Marie Bruandet, Ruben Tamazyan, Claire Join-Lambert, Eric Jüettler, Trudy Millard Krause, S. Maul, Matthias Endres, Gerhard J. Jungehülsing, M. Hennerici, Martin Griebe, Tamara Sauer, K. Knoll, R. Huber, K. Knauer, C. Michael Knauer, S. Raubold, H. Schneider, H. Hentschel, C. Lautenschläger, Eik Schimmel, Imanuel Dzialowski, Christian Foerch, Matthias Lorenz, O.C. Singer, Igor Martins Santos, A. Hartmann, A. Hamann, Alexander Schacht, Bruce J. Schrader, A. Teíchmann, Katja E. Wartenberg, Thomas J. J. Mueller, Sławomir Jander, Michael Gliem, Claudia Boettcher, Michael Rosenkranz, Cynthia A Beck, Dörte Otto, Götz Thomalla, Bastian Cheng, Kam Sing Wong, Thomas Leung, Y.O.Y. Soo, S. Prabhakar, S.R. Kesavarapu, P.K. Gajjela, R.R. Chenna, K. Ummer, Maamoun Basheer, A. Andipet, M.K.M. Jagarlapudi, Ashfaq Mohammed, Vishwajeet Pawar, S.S.K. Eranki, Jeyaraj Pandian, Y. Singh, Nasim Akhtar, Nomal Chandra Borah, M. Ghose, Nusrat Choudhury, N.R. Ichaporia, J. Shendge, S. Khese, Vijaya Pamidimukkala, P. Inbamuthaiah, Sushma Nuthakki, N.M.R. Tagallamudi, A.K. Gutti, Dheeraj Khurana, P. Kesavarapu, V. Jogi, Amita Garg, Damayanti Samanta, G.R.K. Sarma, Raghunandan Nadig, Thomas Mathew, M.A. Anandan, E. Caterbi, Andrea Zini, Milena Cavazzuti, Federica Casoni, Roberta Pentore, Francesca Maria Antonella Falzone, Stefano Ricci, Tatiana Mazzoli, Lisa Greco, C. Menichetti, Francesca Coppola, Sabine Cenciarelli, E. Gallinella, A. Mattioni, R Condurso, I. Sicilia, Mauro Zampolini, Francesco Corea, Mali Barbi, Costanza Proietti, Danilo Toni, Andréa Pieroni, A. Anzini, Anne Falcou, M. Demichele, Catharina J.M. Klijn, Arnstein Tveiten, Erik Thomas Thortveit, S. Pettersen, N. Holand, B. Hitland, Stein Harald Johnsen, Agnethe Eltoft, Mohammad Wasay, A. Kamal, Ambreen Iqrar, Latisha K. Ali, Dil Begum, G. Gama, Elsa Azevedo, L. Fonseca, G. Moreira, L.M. Veloso, Diego Pinheiro, Laura Gallego Paredes, C. Rozeira, Tiago Gregório, Tomás Segura, Ó. Ayo, Javier Garcı́a-Garcı́a, Inmaculada Feria-Vilar, I. Gómez Fernández, Ángel Chamorro, Sergio Amaro, Xabier Urra, Vı́ctor Obach, Álvaro Cervera, J. Trueta, Yolanda Silva, Joaquı́n Serena, Mar Castellanos, Mikel Terceño, Cecile van Eendenburg, Urs Fischer, Marilyn Arnold, Anja Weck, Oliver Findling, R. Lüdi, Elizabeth A. Warburton, Diana J. Day, N. Butler, E. Bumanlag, S. Caine, A. Steele, Michael J. Osborn, Erin Dodd, Patrick Murphy, Bernard Esisi, Eli M. Brown, R. Hayman, V. K.V. Baliga, M. Minphone, J. Kennedy, Ian Reckless, George Pope, Rachel Teal, K. Michael, Dulka Manawadu, Lalit Kalra, R. Lewis, B. Mistry, E. Cattermole, Amin Hassan, L. Mandizvidza, John Bamford, H. L. Brooks, C. Bedford, R.L. Whiting, Paul Baines, M. Hussain, Mark Harvey, K. Fotherby, Scott McBride, Paula Bourke, D. Morgan, Karla Jennings-Preece, Christopher Price, S. Huntley, V.E. Riddell, G. Storey, Rachel Lakey, G. Subramanian, Damian Jenkinson, Joseph Kwan, Olivier David, D. Tiwari, Martin James, Sharon Keenan, H. Eastwood, L. Shaw, Philip Kaye, D. Button, B. Madigan, D. Williamson, A. Dixit, Joshua S. Davis, M.O. Hossain, Gary A. Ford, Adrian Parry‐Jones, V. O'Loughlin, R. Jarapa, Zin Naing, Caroline Lovelock, John O’Reilly, Ubaid Khan, Aneil Bhalla, A. G. Rudd, Jonathan Birns, David J. Werring, Ryan Law, Richard Perry, I. Jones, Renuka Erande, Christine Roffe, Indira Natarajan, Naveed Ahmad, K. Finney, J. Lucas, Amit Mistri, D. Eveson, Reginald Marsh, Victoria J. Haunton, Thompson Robinson, A.A. Rabinstein, Jennifer Fugate, S. Lepore - Neurology 2017 被引用: 144

OBJECTIVE: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). METHODS: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. RESULTS: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). CONCLUSION: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. CLINICALTRIALSGOV REGISTRATION: NCT00716079.