A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix

Howard Seeherman; Stephen P. Berasi; Christopher Brown; Robert Martinez; Z. Sean Juo; Scott A. Jelinsky; Michael Cain; Jaclyn Grode; Kathleen E. Tumelty; Marc Bohner; Orly Grinberg; Nadav Orr; Oded Shoseyov; Jeroen Eyckmans; Christopher S. Chen; Pablo Morales; Christopher G. Wilson; Eric J. Vanderploeg; John M. Wozney

doi:10.1126/scitranslmed.aar4953

A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix

著者: Howard Seeherman, Stephen P. Berasi, Christopher Brown, Robert Martinez, Z. Sean Juo, Scott A. Jelinsky, Michael Cain, Jaclyn Grode, Kathleen E. Tumelty, Marc Bohner, Orly Grinberg, Nadav Orr, Oded Shoseyov, Jeroen Eyckmans, Christopher S. Chen, Pablo Morales, Christopher G. Wilson, Eric J. Vanderploeg, John M. Wozney - Science Translational Medicine 2019 被引用: 68

of the BMP-2/absorbable collagen sponge (ACS) concentration approved for clinical use. Initial toxicology studies were negative. These results support evaluations of BV-265/CM as an alternative to BMP-2/ACS in clinical trials for orthopedic conditions requiring augmented healing.