The intestinal microbiota and metabolites in patients with anorexia nervosa

著者: Petra Procházková, Radka Roubalová, Jiří Dvořák, Jakub Kreisinger, Martin Hill, Helena Tlaskalová‐Hogenová, Petra Tomášová, Helena Pelantová, M Čermáková, Marek Kuzma, Josef Bulant, Martin Bilej, Kvido Smitka, Alena Lambertová, Petra Holanová, Hana Papežová - Gut Microbes 2021 被引用: 136

. Patients exhibited greater interindividual variation in the gut bacteriome, as well as in metagenome content compared to controls, suggesting altered bacteriome functions. Patients had decreased levels of serotonin, GABA, dopamine, butyrate, and acetate in their stool samples compared to controls. Mycobiome analysis did not reveal significant differences in alpha diversity and fungal profile composition between patients with AN and healthy controls, nor any correlation of the fungal composition with the bacterial profile. Our results show the changed profile of the gut microbiome and its metabolites in patients with severe AN. Although therapeutic partial renourishment led to increased body mass index and improved psychometric parameters, SCFA, and neurotransmitter profiles, as well as microbial community compositions, did not change substantially during the hospitalization period, which can be potentially caused by only partial weight recovery.