Pseudomonas aeruginosa transcriptome during human infection

著者: Daniel M. Cornforth, Justine L. Dees, Carolyn B. Ibberson, Holly Huse, Inger Hee Mabuza Mathiesen, Klaus Kirketerp‐Møller, Randy Wolcott, Kendra P. Rumbaugh, Thomas Bjarnsholt, Marvin Whiteley - Proceedings of the National Academy of Sciences, PNAS 2018 被引用: 288

Significance Microbiologists typically use laboratory systems to study the bacteria that infect humans. Over time, this has created a gap between what researchers understand about bacteria growing in the laboratory and those growing in humans. It is well-known that the behavior of bacteria is shaped by their environment, but how this behavior differs in laboratory models compared with human infections is poorly understood. We compared transcription data from a variety of human infections with data from a range of in vitro samples. We found important differences in expression of genes involved in antibiotic resistance, cell–cell communication, and metabolism. Understanding the bacterial expression patterns in human patients is a necessary step toward improved therapy and the development of more accurate laboratory models.