Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses

著者: Karl L. Banta, Xiaozheng Xu, Avantika S. Chitre, Amelia Au‐Yeung, Chikara Takahashi, William O’Gorman, Thomas D. Wu, Stephanie Mittman, Rafael Cubas, Laëtitia Comps‐Agrar, Amit Fulzele, Eric J. Bennett, Jane L. Grogan, Enfu Hui, Eugene Y. Chiang, Ira Mellman - Immunity 2022 被引用: 347

T cell responses, requires blockade of TIGIT and PD-1, providing a mechanistic rationale for combinatorial targeting in the clinic.