Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2

著者: Dongliang Wang, Chaoshuai Zhao, Fei Xu, Aimi Zhang, Mingming Jin, Kunchi Zhang, Liu Liu, Qian Hua, Jian Zhao, Jianjun Liu, Hao Yang, Gang Huang - Theranostics 2021 被引用: 226

Our findings revealed that hypoxia-induced exosomes transmit cisplatin resistance to sensitive NSCLC cells by delivering PKM2. Exosomal PKM2 may serve as a promising biomarker and therapeutic target for cisplatin resistance in NSCLC.