ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases

著者: Michael R. Jacobs, Ayman M. Abdelhamed, Caryn E. Good, Daniel D. Rhoads, Kristine M. Hujer, Andrea M. Hujer, Tatiana Domitrovic, Susan D. Rudin, Sandra S. Richter, David van Duin, Barry N. Kreiswirth, Chris Greco, Derrick E. Fouts, Robert A. Bonomo - Antimicrobial Agents and Chemotherapy 2018 被引用: 110

The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia , Pseudomonas aeruginosa , and Enterobacteriaceae strains was determined by microdilution in iron-depleted Mueller-Hinton broth.