Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis

著者: Catherine Y. Cheng, Nuria Martinez Gutierrez, Mardiana Marzuki, Xiaohua Lu, Taylor W. Foreman, Bhairav Paleja, Bernett Lee, Akhila Balachander, Jinmiao Chen, Liana Tsenova, Natalia Kurepina, Karen Wei Weng Teng, Kim West, Smriti Mehra, Francesca Zolezzi, Michael Poidinger, Barry N. Kreiswirth, Deepak Kaushal, Hardy Kornfeld, Evan W. Newell, Amit Singhal - Science Immunology 2017 被引用: 132

infection. Collectively, these results provide a link between SIRT1 activation and TB pathogenesis and indicate a potential of SIRT1 activators in designing an effective and clinically relevant host-directed therapies for TB.