CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies

著者: Diogo Gomes‐Silva, Madhuwanti Srinivasan, Sandhya Sharma, Ciaran M. Lee, Dimitrios L. Wagner, Timothy Davis, Rayne H. Rouce, Gang Bao, Malcolm K. Brenner, Maksim Mamonkin - Blood 2017 被引用: 463

) T and NK lymphocytes, we show that the CD7-edited T cells themselves can respond to viral peptides and therefore could be protective against pathogens. Hence, genomic disruption of a target antigen overcomes fratricide of CAR T cells and establishes the feasibility of using CD7 CAR T cells for the targeted therapy of T-cell malignancies.