High prevalence of myeloid neoplasms in adults with non–Langerhans cell histiocytosis

著者: Matthias Papo, Eli L. Diamond, Fleur Cohen‐Aubart, Jean‐François Emile, Damien Roos‐Weil, Nishant Gupta, Benjamin H. Durham, Neval Özkaya, Ahmet Doǧan, Gary A. Ulaner, Raajit K. Rampal, Jean‐Emmanuel Kahn, Thomas Sené, Frédéric Charlotte, B. Hervier, Caroline Besnard, Olivier Bernard, Catherine Settegrana, Nathalie Droin, Zofia Hélias‐Rodzewicz, Zahir Amoura, Omar Abdel‐Wahab, Julien Haroche - Blood 2017 被引用: 147

mutations). Histiocytosis patients diagnosed with a concomitant myeloid malignancy were significantly older at diagnosis and more commonly presented with MH than those without a myeloid malignancy. In some cases, the presence of distinct kinase mutations in the histiocytosis and myeloid neoplasm resulted in discordant and adverse responses to kinase-directed targeted therapies. These data highlight the clinical importance of evaluating adults with histiocytosis for a concomitant myeloid neoplasm.