Facile and General Synthesis of Photoactivatable Xanthene Dyes

著者: Laura M. Wysocki, Jonathan B. Grimm, Ariana N. Tkachuk, Timothy A. Brown, Eric Betzig, Luke D. Lavis - Angewandte Chemie International Edition 2011 被引用: 139

Despite the apparent simplicity of the xanthene fluorophores, the preparation of caged derivatives with free carboxy groups remains a synthetic challenge. A straightforward and flexible strategy for preparing rhodamine and fluorescein derivatives was developed using reduced, “leuco” intermediates.