Mitochondrial DNA Promotes NLRP3 Inflammasome Activation and Contributes to Endothelial Dysfunction and Inflammation in Type 1 Diabetes

著者: Camila A. Pereira, Daniela Carlos, Nathanne S. Ferreira, Josiane F. Silva, Camila Z. Zanotto, Dario S. Zamboni, Valéria Duarte Garcia, Dora Fix Ventura, João S. Silva, Rita C. Tostes - Frontiers in Physiology 2020 被引用: 85

influx and mitochondrial ROS generation. NLRP3 deficiency prevents diabetes-associated vascular inflammatory damage and endothelial dysfunction. Our study highlights the importance of NLRP3 inflammasome in diabetes-associated vascular dysfunction, which is key to diabetic complications.