RETRACTED: HOXA5-miR-574-5p axis promotes adipogenesis and alleviates insulin resistance

著者: Yuying Li, Jiayin Li, Haibo Yu, Yanxia Liu, Haixu Song, Xiaoxiang Tian, Dan Liu, Chenghui Yan, Yaling Han - Molecular Therapy — Nucleic Acids 2021 被引用: 18

, a direct downstream target of miR-574-5p, was involved in the regulation of adipocyte differentiation. The overexpression of miR-574-5p also promoted adipogenesis in subcutaneous fat to alleviate IR in high-fat-diet-fed mice. Additionally, miR-574-5p expression was significantly higher in the subcutaneous adipose tissue of obese patients without type 2 diabetes than in those with type 2 diabetes. There was an increase in HOXA5 expression and a decrease in histone deacetylase 9 (HDAC9) expression in the subcutaneous fat of obese patients without type 2 diabetes. These results suggest that miR-574-5p may be a potential therapeutic target for combating obesity-related IR.