Asymmetric total synthesis of erythromycin. 3. Total synthesis of erythromycin

著者: R. B. Woodward, Eugene W. Logusch, K. P. Nambiar, Kunio Sakan, Dale E. Ward, B. W. Au-Yeung, P. Balaram, Leslie J. Browne, Peter J. Card, C. H. Chen - Journal of the American Chemical Society 1981 被引用: 204

In the preceding paper' we described the preparation of the key lactone intermediate la in optically active form. In this paper we report the synthesis of erythromycin (2) from la. In essence,this transformation involves the glycosidation of a suitable derivative of la with L-cladinose and D-desosamine and the generation of the C-9 ketone functionality.