Genomic Diversity, Virulence, and Antimicrobial Resistance ofKlebsiella pneumoniaeStrains from Cows and Humans

著者: Yongqiang Yang, Catherine H. Higgins, Ibraheem Rehman, Klibs N. Galvão, Ilana Brito, M.L.S. Bicalho, Jeongmin Song, Hongning Wang, R.C. Bicalho - Applied and Environmental Microbiology 2019 被引用: 61

We demonstrate here the genetic diversity of K. pneumoniae isolates from dairy cows and the mixed phylogenetic lineages between bovine and human isolates. The ferric uptake operon kfuABC genes were more prevalent in strains from clinical mastitis cows. Furthermore, we report the emergence of an IncN-type plasmid carrying the bla CTX-M-1 and mph (A) genes among dairy farms in the United States. Our study evaluated the genomic diversity of the bovine and human isolates, and the findings uncovered different profiles of virulence determinants among bovine and human K. pneumoniae isolates at the genome population level.