Risk to human health related to the presence of perfluoroalkyl substances in food

著者: EFSA Panel on Contaminants in the Food Chain (EFSA CONTAM Panel), Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Bettina Grasl‐Kraupp, Christer Högstrand, L.A.P. Hoogenboom, Jean‐Charles Leblanc, Carlo Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Christiane Vleminckx, Heather Wallace, Lars Barregård, Sandra Ceccatelli, Jean‐Pierre Cravedi, Þórhallur I. Halldórsson, Line Småstuen Haug, Niklas Johansson, Helle Katrine Knutsen, Martin Rose, Alain‐Claude Roudot, Henk Van Loveren, Günter Vollmer, Karen Mackay, Francesca Riolo, Tanja Schwerdtle - EFSA Journal 2020 被引用: 950

of 17.5 ng/mL for the sum of the four PFASs in serum was identified for 1-year-old children. Using PBPK modelling, this serum level of 17.5 ng/mL in children was estimated to correspond to long-term maternal exposure of 0.63 ng/kg bw per day. Since accumulation over time is important, a tolerable weekly intake (TWI) of 4.4 ng/kg bw per week was established. This TWI also protects against other potential adverse effects observed in humans. Based on the estimated LB exposure, but also reported serum levels, the CONTAM Panel concluded that parts of the European population exceed this TWI, which is of concern.