HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway

著者: Yajin Liao, Jinbo Cheng, Xiangxi Kong, Shuoshuo Li, Xiaoheng Li, Meijuan Zhang, He Zhang, Tianli Yang, Yuan Dong, Jun Li, Yun Xu, Zengqiang Yuan - Theranostics 2020 被引用: 338

Collectively, we elucidated that the HDAC3-p65-cGAS-STING pathway is involved in the development of I/R-induced neuroinflammation, identifying a new therapeutic avenue for the treatment of ischemic stroke.