Seabuckthorn polysaccharide ameliorates high-fat diet-induced obesity by gut microbiota-SCFAs-liver axis

著者: Ying Lan, Qingyang Sun, Zhiyuan Ma, Jing Peng, Mengqi Zhang, Chi Wang, Xiaotian Zhang, Xianfang Yan, Lili Chang, Xinglin Hou, Ruixue Qiao, Aiziguli Mulati, Yuan Zhou, Qıang Zhang, Zhigang Liu, Xuebo Liu - Food & Function 2021 被引用: 122

, and Streptococcus in HFD-induced obese mice. Moreover, the production of microbial metabolites short-chain fatty acids (SCFAs) in feces has also increased. In addition, correlation analysis results showed that obesity-ameliorating effects of SP were highly associated with levels of SCFAs in feces. Therefore, the regulation of SP on liver lipid metabolism may be due to the variation of the gut microbiome and raised production of SCFAs. These results indicate that SP could play the part of a potential nutraceutical for ameliorating obesity through regulation of the gut-liver axis.