A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO

著者: Joel D. W. Toh, Lingyi Sun, Lisa Z. M. Lau, Jackie Tan, Joanne J. A. Low, Colin W. Q. Tang, Eleanor Jing Yi Cheong, Melissa J. H. Tan, Yun Chen, Wanjin Hong, Yong‐Gui Gao, Esther C. Y. Woon - Chemical Science 2014 被引用: 117

for FTO against other AlkB subfamilies and 2OG oxygenases shall be of considerable interest with regards to its potential use as a functional probe. The strategy outlined here is likely applicable to other AlkB subfamilies, and, more widely, to other 2OG oxygenases.