A global point prevalence survey of antimicrobial use in neonatal intensive care units: The no-more-antibiotics and resistance (NO-MAS-R) study

著者: Pavel Prusakov, Debra A. Goff, Phillip S. Wozniak, Azraa Cassim, Catherine E. A. Scipion, Soledad Urzúa, Andrea Ronchi, Lingkong Zeng, Oluwaseun Ladipo‐Ajayi, Noelia Aviles-Otero, Chisom R. Udeigwe‐Okeke, Rimma Melamed, Rita C. Silveira, Cinzia Auriti, Claudia Beltrán-Arroyave, Elena Zamora-Flores, María Isabel Sánchez-Códez, Eric S. Donkor, Satu Kekomäki, Nicoletta Mainini, Rosalba Vivas Trochez, Jamalyn Casey, Juan M. Graus, Mallory Muller, Sara Singh, Yvette G.T. Loeffen, María Eulalia Tamayo Pérez, Gloria Isabel Ferreyra, Victoria Lima‐Rogel, Barbara Perrone, Giannina Izquierdo, María Cernada, Sylvia Stoffella, Sebastian O. Ekenze, Concepción de Alba-Romero, Chryssoula Tzialla, Jennifer T. Pham, Kenichiro Hosoi, Magdalena Cecilia Calero Consuegra, P Betta, O. Alvaro Hoyos, Emmanuel Roilides, Gabriela Naranjo-Zuñiga, Makoto Oshiro, Victor Garay, Vito Mondı̀, Danila Mazzeo, James A. Stahl, Joseph B. Cantey, Juan Gonzalo Mesa Monsalve, Erik Normann, Lindsay C. Landgrave, Ali Mazouri, Claudia Alarcón Avila, Fiammetta Piersigilli, Mónica Trujillo, Sonya Kolman, Verónica Delgado, Veronica Guzman, Mohamed Abdellatif, Luis Monterrosa, Lucia Gabriella Tina, Khalid Yunis, Marco Antonio Belzu Rodriguez, Nicole Le Saux, Valentina Leonardi, Alessandro Porta, Giuseppe Latorre, Hidehiko Nakanishi, Michal Meir, Paolo Manzoni, Ximena Norero, Ángela Hoyos, Diana Arias, Rubén García Sánchez, Alexandra K Medoro, Pablo J. Sánchez - EClinicalMedicine 2021 被引用: 83

BACKGROUND: Global assessment of antimicrobial agents prescribed to infants in the neonatal intensive care unit (NICU) may inform antimicrobial stewardship efforts. METHODS: We conducted a one-day global point prevalence study of all antimicrobials provided to NICU infants. Demographic, clinical, and microbiologic data were obtained including NICU level, census, birth weight, gestational/chronologic age, diagnoses, antimicrobial therapy (reason for use; length of therapy), antimicrobial stewardship program (ASP), and 30-day in-hospital mortality. FINDINGS: = 0·02). INTERPRETATION: Global NICU antibiotic use was frequent and prolonged regardless of culture results. NICU-specific ASPs were associated with lower antibiotic utilization rates, suggesting the need for their implementation worldwide. FUNDING: Merck & Co.; The Ohio State University College of Medicine Barnes Medical Student Research Scholarship.