“Small Blood Vessels: Big Health Problems?”: Scientific Recommendations of the National Institutes of Health Workshop

著者: Francesca Bosetti, Zorina S. Galis, Margaret S. Bynoe, Marc Charette, Marilyn J. Cipolla, Gregory J. del Zoppo, Douglas B. Gould, Thomas S. Hatsukami, Teresa L.Z. Jones, James I. Koenig, Gerard A. Lutty, Christine Maric‐Bilkan, Troy Stevens, Hatice Tolunay, Walter J. Koroshetz, Dritan Agalliu, David A. Antonetti, Manfred Boehm, Claudette E. Brooks, Kathleen M. Caron, William M. Chilian, Mat J.A.P. Daemen, Robert J. D’Amato, Thomas P. Davis, Adviye Ergul, James E. Faber, R. Ariel Gómez, Peter C. Grayson, Isabella M. Grumbach, Jaime Grutzendler, Chenghua Gu, David S. Gutterman, John M. Hallenbeck, Ira M. Herman, Jay D. Humphrey, Costantino Iadecola, Edward W. Inscho, David Kleinfeld, Eng H. Lo, Jose A. Lopez, Stephen L. Macknik, Asrar B. Malik, Tanya N. Mayadas, Dorian B. McGavern, Gerald A. Meininger, Virginia M. Miller, Maiken Nedergaard, Mark T. Nelson, Shayn M. Peirce, Ipolia Ramadan, Gary A. Rosenberg, Ernesto L. Schiffrin, Peter C. Searson, Nina S. Stachenfeld, Radu V. Stan, Yajaira Suárez, Eroboghene E. Ubogu, Zinaida S. Vexler, Cornelia M. Weyand, Berislav V. Zloković - Journal of the American Heart Association 2016 被引用: 85

S mall blood vessels (generally <100 lm in internal diameter) contribute to fundamental physiological processes and pathological events, but may not necessarily garner the attention associated with macrovascular physiology and disease.Major reasons for the bench-to-bedside research gap is the complexity and the size of small vessels throughout the body.Small vessels contain diverse cellular components and interact with a large variety of nonvascular parenchymal cell populations that differ among various organs.Depending on their location, the overlapping effect of environmental, epigenetic, and developmental factors adds to this complexity, challenging the translation of fundamental discoveries to the bedside.A better understanding of the specific structural and functional signatures of small vessels throughout the body and how their local perturbations can contribute to systemic pathophysiological conditions has the potential to transform diagnostic and therapeutic approaches.To advance this important area of science, the National Institutes of Health held a workshop on September 18-19, 2014 that brought together scientists and clinicians from diverse areas of microvascular research to share their latest discoveries, identify common challenges, and foster collaborative research on the physiology and pathology of small blood vessels in many organs and tissues.The workshop included 7 scientific sessions, entitled: ( 1) Basic Biology and Natural History of Small Vessels; (2) Vascular Dynamics; (3) Small Vessel Cellular Interactions; (4) Transendothelial Transport, Including Across the Blood Brain Barrier (BBB) in Health and Disease; (5) Small Vessels in Disease; (6) Effects of Internal Milieu and Disease on Small Vessels; and (7) Research Tools and Innovation.All sessions and panel discussions are available in the National Institutes of Health Videocast archive (http://videocast.nih.gov/PastE-vents.asp).This white paper is not meant to be a comprehensive review of the topics.Rather it is meant to articulate the gaps and opportunities identified by the workshop participants.We regret any major omissions that might have occurred.The top scientific priorities identified by participants needing further study are summarized in Table.