Nucleophilic Catalysis of Oxime Ligation

著者: Anouk Dirksen, Tilman M. Hackeng, Philip E. Dawson - Angewandte Chemie 2006 被引用: 479

Aniline acts as a nucleophilic catalyst of oxime ligation in aqueous solution through formation of the orange-colored intermediate. The method is demonstrated by acceleration of the oxime ligation of peptides at pH 4.5 and pH 7, which extends the scope of this reaction to conditions relevant for the bioconjugation of macromolecules (see scheme).