DEC2 modulates orexin expression and regulates sleep

著者: Arisa Hirano, Pei-Ken Hsu, Luoying Zhang, Lijuan Xing, Thomas McMahon, Maya Yamazaki, Louis J. Ptáček, Ying‐Hui Fu - Proceedings of the National Academy of Sciences, PNAS 2018 被引用: 79

Significance Sleep is essential for healthy aging, and most people need approximately 8–8-1/2 hours of sleep per night to feel good and to function optimally. We previously reported a proline-to-arginine mutation in DEC2 that leads to a life-long decrease in daily sleep need. We found that the expression of an important sleep-relevant gene, orexin , was increased in the DEC2 mutant mice. Further investigation revealed that DEC2 is a transcriptional repressor for orexin expression, and that mutant DEC2 exerts less repressor activity than WT-DEC2, resulting in increased orexin expression. This study represents the first step toward understanding the underlying molecular mechanism through which DEC2 modulates sleep.