ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2α-Mediated Glycolysis

著者: Hao Yu, Xiao Yang, Jinyuan Tang, Shuhui Si, Zijian Zhou, Jiancheng Lu, Jie Han, Baorui Yuan, Qikai Wu, Qiang Lü, Haiwei Yang - Molecular Therapy — Nucleic Acids 2020 被引用: 236

, whereas ALKBH5 overexpression led to the opposite results. Finally, ALKBH5 inhibited the progression and sensitized bladder cancer cells to cisplatin through a casein kinase 2 (CK2)α-mediated glycolysis pathway in an m6A-dependent manner. Taken together, these findings might provide fresh insights into bladder cancer therapy.