NLRP6 Protects Il10 Mice from Colitis by Limiting Colonization of Akkermansia muciniphila

著者: Sergey S. Seregin, Natasha B. Golovchenko, Bryan Schaf, Jiachen Chen, Nicholas A. Pudlo, Jonathan Mitchell, Nielson T. Baxter, Lili Zhao, Patrick D. Schloss, Eric C. Martens, Kathryn A. Eaton, Grace Chen - Cell Reports 2017 被引用: 384

(Cell Reports 19, 733–745; April 25, 2017) In the originally published version of this article, the Supplemental Experimental Procedures were accidentally omitted. The Supplemental Experimental Procedures now appear with the article online. The authors regret this error. NLRP6 Protects Il10−/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphilaSeregin et al.Cell ReportsApril 25, 2017In BriefNLRP6 is important for maintaining intestinal homeostasis. Seregin et al. demonstrate that NLRP6 limits the colonization of mucolytic A. muciniphila, which is sufficient to induce colitis in specific-pathogen-free and germ-free Il10−/− mice. Resistance to A. muciniphila colonization by NLRP6 is mediated by IL-18. Full-Text PDF Open Access