Development of hypoxia-activated PROTAC exerting a more potent effect in tumor hypoxia than in normoxia

著者: Weiyan Cheng, Shasha Li, Xueqian Wen, Siyuan Han, Suhua Wang, Wei Han, Zhizhen Song, Yueqin Wang, Xin Tian, Xiaojian Zhang - Chemical Communications 2021 被引用: 118

in hypoxia than in normoxia in HCC4006 cells. This is the first example of identifying a PROTAC to selectively act on tumors utilizing the characteristic of tumor hypoxia and provides a new approach for PROTAC development.