Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome

著者: Isabel Pablos, Yoan Machado, Hugo César Ramos de Jesus, Yasir Mohamud, Reinhild Kappelhoff, Cecilia Lindskog, Marli Vlok, Peter A. Bell, Georgina S. Butler, Peter M. Grin, Quynh Cao, Jenny Nguyen, Nestor Solis, Srinivas Abbina, Wioletta Rut, John C. Vederas, László Székely, Attila Szakos, Marcin Drąg, Jayachandran N. Kizhakkedathu, Karen Mossman, Jeremy A. Hirota, Eric Jan, Honglin Luo, Arinjay Banerjee, Christopher M. Overall - Cell Reports 2021 被引用: 108

Highlights d An atlas of 101 human cell substrates of SARS-CoV-2 3CL pro and 58 candidate substrates is presented d SARS-CoV-2 3CL pro redundantly targets the hippo and antiviral xenophagy pathways d Galectin-8 binds as an intracellular sensor for CoV-2 spike protein that 3CL pro cuts d Cytosolic translocation of PTBP1 from the nucleus follows proteolytic removal of an NLS