GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment

著者: Marie Jo Halaby, Kebria Hezaveh, Sara Lamorte, M. Teresa Ciudad, Andreas Kloetgen, Bethany MacLeod, Mengdi Guo, Ankur Chakravarthy, Tiago da Silva Medina, Stefano Ugel, Aristotelis Tsirigos, Vincenzo Bronte, David H. Munn, Trevor J. Pugh, Daniel D. De Carvalho, Marcus O. Butler, Pamela S. Ohashi, David G. Brooks, Tracy L. McGaha - Science Immunology 2019 被引用: 186

by small interfering RNA knockdown reduced tumor growth. Last, analysis of patients with cutaneous melanoma showed that GCN2-dependent transcriptional signatures correlated with macrophage polarization, T cell infiltrates, and overall survival. Thus, these data reveal a previously unknown dependence of tumors on myeloid GCN2 signals for protection from immune attack.