cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy

著者: Wenwen Li, Lu Lu, Juanjuan Lu, Xinran Wang, Chao Yang, Jingsi Jin, Lingling Wu, Xiaochuan Hong, Fanlin Li, Dongqing Cao, Yuanqin Yang, Meng Wu, Bing Su, Jinke Cheng, Xuanming Yang, Wen Di, Liufu Deng - Science Translational Medicine 2020 被引用: 286

T cells from patients with cancer and potentiated antitumor responses of CAR-T cell therapy in a xenograft model. These findings advance our understanding of inherent cGAS-STING activation in T cells and provide insight into the development of improved T cell therapy by harnessing the cGAS-STING pathway for cancer immunotherapy.