Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8 + T cells

著者: Son Nguyen, Claire Deléage, Samuel Darko, Amy Ransier, Duc P. Truong, Divyansh Agarwal, Alberto Sada Japp, Vincent H. Wu, Leticia Kuri-Cervantes, Mohamed Abdel‐Mohsen, Perla M. Del Río Estrada, Yuria Ablanedo‐Terrazas, Emma Gostick, James A. Hoxie, Nancy R. Zhang, Ali Naji, Gustavo Reyes‐Terán, Jacob D. Estes, David A. Price, Daniel C. Douek, Steven G. Deeks, Marcus Buggert, Michael R. Betts - Science Translational Medicine 2019 被引用: 127

T cells from the LNs of ECs, typified by the down-regulation of inhibitory receptors and cytolytic molecules and the up-regulation of multiple cytokines, predicted secreted factors, and components of the protein translation machinery. Collectively, these results provide a mechanistic framework to expedite the identification of novel antiviral factors, highlighting a potential role for the localized deployment of noncytolytic functions as a determinant of immune efficacy against HIV.