Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

著者: Jeremy A. Meier, Moonjung Hyun, Marc Cantwell, Ali Raza, Claudia Mertens, Vidisha Raje, Jennifer D. Sisler, Erin Tracy, Sylvia Torres-Odio, Suzana Gispert, Peter E. Shaw, Heinz Baumann, Dipankar Bandyopadhyay, Kazuaki Takabe, Andrew C. Larner - Science Signaling 2017 被引用: 105

in STAT3 and new protein synthesis. Under these conditions, mitochondrially localized STAT3 also became competent to bind to cyclophilin D (CypD). Binding of STAT3 to CypD was mediated by the amino terminus of STAT3, which was also important for reducing mitochondrial ROS production after oxidative stress. These results outline a role for mitochondrially localized STAT3 in sensing and responding to external stimuli.