Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors

著者: Bruno L. Cadilha, Mohamed-Reda Benmebarek, Klara Dorman, Arman Öner, Theo Lorenzini, Hannah Obeck, Mira Vänttinen, Mauro Di Pilato, Jasper N. Pruessmann, Stefan Stoiber, Duc Huynh, Florian Märkl, Matthias Seifert, Katrin Manske, Javier Suárez-Gosálvez, Yi Zeng, Stefanie Lesch, Clara H. Karches, Constanze Heise, Adrian Gottschlich, Moritz Thomas, Carsten Marr, Jin Zhang, Dharmendra Pandey, Tobias Feuchtinger, Marion Subklewe, Thorsten R. Mempel, Stefan Endres, Sebastian Kobold - Science Advances 2021 被引用: 102

T cell recruitment to the tumor site. This sustained and improved infiltration of engineered T cells synergized with TGF-β shielding for improved therapeutic efficacy. Our results demonstrate that addition of CCR8 and DNR into CAR T cells can render them effective in solid tumors.