Integrated genomic characterization of oesophageal carcinoma

著者: Young Soo Park, Jihun Kim, Rebecca Carlsen, Reanne Bowlby, Marco A. Marra, Robert A. Holt, Steven J. M. Jones, Adrian Ally, Denise Brooks, Angela Tam, Miruna Balasundaram, Payal Sipahimalani, Haiyan I. Li, Karen L. Mungall, Richard A. Moore, Tina Wong, Reanne Bowlby, Eric Chuah, Michael Mayo, Jacqueline E. Schein, Yussanne Ma, Katayoon Kasaian, Noreen Dhalla, Andrew J. Mungall, A. Gordon Robertson, Nina Thiessen, Robert D. Odze, Matthew Meyerson, Robert D. Odze, Nils Gehlenborg, Kristian Cibulskis, Andrew D. Cherniack, Michael S. Lawrence, Jaegil Kim, Timothy Defrietas, Michael S. Noble, Michael Lawrence, Doug Voet, Andrew Dunford, Juliann Shih, David I. Heiman, Amaro Taylor-Weiner, Gad Getz, Eric Lander, Lynda Chin, Carrie Cibulskis, Bradley A. Murray, Pei Lin, Andrew D. Cherniack, Paz Polak, Susan Bullman, Gad Getz, Scott Frazer, Chandra Sekhar Pedamallu, Rameen Beroukhim, Gordon Saksena, Chip Stewart, Stacey B. Gabriel, Stacey Gabriel, Samuel R. Meier, Juok Cho, Hailei Zhang, Steven E. Schumacher, Matthew Meyerson, Chandra Sekhar Pedamallu, Rameen Beroukhim, Susan Bullman, Juliann Shih, Andrew D. Cherniack, Sarah Derks, Adam J. Bass, Juliann Shih, Benjamin J. Raphael, Alexandra M. Wong, Hsin-Ta Wu, Benjamin J. Raphael, Joseph E. Willis, Joseph E. Willis, Adam J. Bass, Sarah Derks, Shannon J. McCall, Crystal Cates, Katherine Garman, Alexis Sharp, Maciej Wiznerowicz, Maciej Wiznerowicz, Michael Parfenov, Xiaojia Ren, Angeliki Pantazi, Melanie Kucherlapati, Raju Kucherlapati, Angela Hadjipanayis, Angeliki Pantazi, Alexei Protopopov, Angeliki Pantazi, Xiaojia Ren, Angeliki Pantazi, Ilya Shmulevich, Ilya Shmulevich, Vésteinn Thorsson, Sheila M. Reynolds, Vésteinn Thorsson, Michael Miller, Brady Bernard, Lisa Iype, Varsha Dhankani, Ryo Sakai, Ryo Sakai, Kenneth Wang, Francisco Sánchez-Vega, Jianjiong Gao, Debyani Chakravarty, Nikolaus Schultz, Joshua Armenia, Ritika Kundra, Nikolaus Schultz, Hongxin Zhang, Nikolaus Schultz, Arshi Arora, Ronglai Shen, Nikolaus Schultz, Nils Weinhold, Kjong-Van Lehmann, Adam Abeshouse, Chris Sander, Nils Weinhold, David Kelsen, David P. Kelsen, Yelena Janjigian, Kenna R. Mills Shaw, John A. Demchok, Margi Sheth, Martin L. Ferguson, Roy Tarnuzzer, Liming Yang, John Demchok, Jiashan Zhang, Zhining Wang, Jean Claude Zenklusen, Julia Zhang, Ina Felau, Jean Claude Zenklusen, M. Constanza Camargo, M. Constanza Camargo, Charles S. Rabkin, Kristen M. Leraas, Kristen Leraas, Lisa Wise, Tara M. Lichtenberg, Jay Bowen, Jay Bowen, Mark Gerken, Erik Zmuda, Jessica Frick, Nilsa C. Ramirez, Julie M. Gastier-Foster, Christina Curtis, Jose A. Seoane, Akinyemi I. Ojesina, Akinyemi I. Ojesina, David G. Beer, Daysha Ferrer-Torres, Margaret L. Gulley, James D. Luketich, James Luketich, Arjun Pennathur, Arjun Pennathur, Zhongren Zhou, Daniel J. Weisenberger, Daniel J. Weisenberger, Wenbin Liu, Rehan Akbani, Rehan Akbani, Apruva Hegde, Wenbin Liu, John N. Weinstein, Gordon B. Mills, Ju-Seog Lee, Gordon Mills, Yiling Lu, Wei Zhang, Brian J Reid, Peter W. Laird, Toshinori Hinoue, Hui Shen, Toshinori Hinoue, M. Blanca Piazuelo, Barbara G. Schneider, Michael McLellan, Elizabeth L. Appelbaum, Lucinda A. Fulton, Elaine R. Mardis, Michael D. McLellan, Robert S. Fulton, Heather K. Schmidt, Richard K. Wilson, Catrina C. Fronick, Matthew G. Cordes, Christopher A. Miller, Li Ding, Nils Gehlenborg, Lixing Yang, Semin Lee, Amaro Taylor-Weiner, Peter J. Park, Peter J. Park, Gad Getz, Gad Getz, Paz Polak, Li Ding, Rameen Beroukhim, Steven E. Schumacher, Angela Hadjipanayis, Melanie Kucherlapati, Raju Kucherlapati, Peter J. Park, Stephen B. Baylin, Katherine A. Hoadley, Phillip H. Lai, Mario Berrios, Andrea Holbrook, Moiz S. Bootwalla, David J. Van Den Berg, Kenna R. Mills Shaw, Hee-Jin Jang, Jun-Eul Hwang, Bo Hwa Sohn, Ju-Seog Lee, Jun-Eul Hwang, Lynda Chin, Christopher A. Bristow, Jianhua Zhang, Jiabin Tang, Lynda Chin, Sahil Seth, Harshad S. Mahadeshwar, Alexei Protopopov, Xingzhi Song, Marc Ladanyi, Laura Tang, Marc Ladanyi, Amie Radenbaugh, Daniel Crain, Robert Penny, Candace Shelton, Johanna Gardner, Troy Shelton, Candace Shelton, David Mallery, Robert Penny, Scott Morris, Erin Curley, Joseph Paulauskis, Katherine Tarvin, Charles Saller, Michael Button, Andre L. Carvalho, Rui Manuel Reis, Rui Manuel Reis, Marcus Medeiros Matsushita, Fabiano Lucchesi, Antonio Talvane de Oliveira, Xuan Le, Galiya Setdikova, Oxana Paklina, Jae-Hyuck Lee, Mary Iacocca, Lori Huelsenbeck-Dill, Joseph Bennett, Olga Voronina, Victoria Fulidou, Olga Potapova, Ouida Liu, Allan Pickens, Seth Force, Suresh Ramalingam, Gabriel Sica, Madhusmitara Behera, Fadio Khuri, Taofeek Owonikoko, Winand Dinjens, Anna van Nistelrooij, Bas Wijnhoven, Anna van Nistelrooij, George Sandusky, Serghei Stepa, Hartmut Juhl, Carsten Zornig, Sun Young Kwon, Hark Kyun Kim, John Bartlett, Jeremy Parfitt, Jennifer Knox, Rebecca Wong, Geoffrey Liu, Haila El-Zimaity, Runjan Chetty, Gail Darling, Alex Boussioutas, Do Young Park, Rafael Kemp, Ajith Kumar Sankarankutty, Jose Sebastião dos Santos, Daniela Pretti da Cunha Tirapelli, Carlos Gilberto Carlotti, Felipe Amstalden Trevisan, Fabiano Pinto Saggioro, Houtan Noushmehr, Jennifer Eschbacher, Michael Dubina, Eugene Mozgovoy, Sally Chalmers, Ian Forgie, Frank Carey, Zaid Naima, Colleen Reilly, Rashna Madan, Andrew Godwin, Michele Vinco, W. Kimryn Rathmell, Rajiv Dhir, Jaffer A. Ajani, Jaffer A. Ajani, Jae-Ho Cheong, Sudha Chudamani, Laxmi Lolla, Jai Liu, Ye Wu, Qiang Sun, Yunhu Wan, Todd Pihl, Rashi Naresh, Heidi J. Sofia, Carolyn M. Hutter - Nature 2017 被引用: 1,890

Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of human papillomavirus. Squamous cell carcinomas showed frequent genomic amplifications of CCND1 and SOX2 and/or TP63, whereas ERBB2, VEGFA and GATA4 and GATA6 were more commonly amplified in adenocarcinomas. Oesophageal adenocarcinomas strongly resembled the chromosomally unstable variant of gastric adenocarcinoma, suggesting that these cancers could be considered a single disease entity. However, some molecular features, including DNA hypermethylation, occurred disproportionally in oesophageal adenocarcinomas. These data provide a framework to facilitate more rational categorization of these tumours and a foundation for new therapies.