Reprogramming of DNA methylation at NEUROD2-bound sequences during cortical neuron differentiation

著者: Maria A. Hahn, Seung‐Gi Jin, Arthur X. Li, Jiancheng Liu, Zhijun Huang, Xiwei Wu, Byung-Wook Kim, Jennifer Johnson, Adrienne-Denise V. Bilbao, Shu Tao, Jacob A. Yim, Yuman Fong, Sandra Goebbels, Markus H. Schwab, Qiang Lü, Gerd P. Pfeifer - Science Advances 2019 被引用: 47

knockout mice, and inducible expression of NEUROD2 caused TET2-associated demethylation at its in vivo binding sites. The data suggest that the reorganization of DNA methylation in developing neurons involves NEUROD2 and TET2-mediated DNA demethylation.