Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development

著者: Ann Hellström, David Ley, Ingrid Hansen‐Pupp, Boubou Hallberg, Chatarina Löfqvist, Linda Van Marter, Mirjam M. van Weissenbruch, Luca A. Ramenghi, Kathryn Beardsall, David B. Dunger, Anna‐Lena Hård, Lois E. H. Smith - Acta Paediatrica 2016 被引用: 183

UNLABELLED: Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities. CONCLUSION: There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.