Effects of empagliflozin on progression of chronic kidney disease: a prespecified secondary analysis from the empa-kidney trial

著者: Natalie Staplin, Richard Haynes, PK Judge, Christoph Wanner, Julie Green, Jonathan Emberson, David Preiss, KJ Mayne, SYA Ng, Emily Sammons, Dandan Zhu, Michael Hill, W. Grant Stevens, Karl Wallendszus, S Brenner, AK Cheung, Zhihong Liu, J Li, LS Hooi, Wenjun Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Z.I. Cherney, Aldo P. Maggioni, Roberto Pontremoli, Rajat Deo, Shinichi Goto, Xavier Rosselló, Katherine R. Tuttle, Dominik Steubl, Michaela Petrini, Siegfried Seidi, Martin Landray, Colin Baigent, WG Herrington, Sharirose Abat, Riaz Rahman, Rizna Abdul Cader, MI Abdul Hafidz, MZ Abdul Wahab, NK Abdullah, Talal Abdulsamad, Masami Abe, Ned Abraham, Sarah Acheampong, P Achiri, JA Acosta, A A Adeleke, Vicki Adell, R Adewuyi-Dalton, Nihad Adnan, A Africano, Mohsen Agharazii, Frank G. Aguilar, A Aguilera, M Ahmad, MK Ahmad, NA Ahmad, NH Ahmad, NI Ahmad, Norazinizah Ahmad Miswan, H Ahmad Rosdi, Iffat Ahmed, Sofia B. Ahmed, Sofia B. Ahmed, Joan Aiello, Alastair Aitken, R AitSadi, Sendogan Aker, S Akimoto, Akinwande A. Akinfolarin, S. Akram, Federico Alberici, Christian Albert, Luke Aldrich, M Alegata, Lacy M. Alexander, S Alfaress, Mohammad Alhadj Ali, A Ali, A Ali, Radica Z. Alicic, Arta Aliu, Ricardo López Almaraz, Rashid Almasarwah, Jussara Carnevale de Almeida, Alessia Aloisi, Laith Al‐Rabadi, Mark Dominik Alscher, Pedro Álvarez, Bader Al-Zeer, M. Ochoa de Olza Amat, Christopher S. Ambrose, Hany Ammar, Yu An, L Andriaccio, K Ansu, A Apostolidi, N. Arai, Hiroaki Araki, Shin‐ichi Araki, A Arbi, O Arechiga, Sarah Armstrong, Taylor J. Arnold, S Aronoff, W Arriaga, J Arroyo, Daniel Arteaga, Shingo Asahara, Akira Asai, N Asai, S Asano, M Asawa, M.F. Asmee, Filippo Aucella, Marc Augustin, Amanda Avery, Ahmed K. Awad, IY Awang, Motoharu Awazawa, A Axler, W Ayub, Zaid Azhari, Rocco Baccaro, C Badin, Benjamin M. Bagwell, Elisabeth Bahlmann-Kroll, AZ Bahtar, Colin Baigent, Diksha Bains, Harpreet S. Bajaj, Rebecca Baker, Enke Baldini, Bernhard Banas, Debasish Banerjee, Shogo Banno, Shweta Bansal, Simona Barberi, Stephen L. Barnes, Cecilia Barnini, C Barot, Kelly M. Schiabor Barrett, R Barrios, B Bartolomei Mecatti, I Barton, Janet Barton, W Basily, Sunita Bavanandan, Alex Baxter, Lewis C. Becker, Srinivasan Beddhu, Joachim Beige, S.A. Beigh, Samira Bell, Urs Benck, Amanda Beneat, Aisleen Bennett, David Bennett, Sarah Benyon, Jocelyn Berdeprado, Tobias Bergler, Albrecht Bergner, Marla J. Berry, Michele Bevilacqua, J Bhairoo, Sudhir Bhandari, Netra Prakash Bhandary, Ankeet S. Bhatt, Mukul Bhattarai, Mansi Bhavsar, W Bian, Francesca Bianchini, Simone Bianco, R. W. Bilous, Jennifer Bilton, Donatella Bilucaglia, C Bird, Divya Birudaraju, M Biscoveanu, Christine E. Blake, Nina Bleakley, K Bocchicchia, Sue C. Bodine, Richard Bodington, Simone Cosima Boedecker-Lips, Marie-Ève Bolduc, Shaun Bolton, Christopher Bond, Fadia El Boreky, Kenneth Boren, Ryotaro Bouchi, Laura Bough, Danijela Bovan, Chris Bowler, Louise Bowman, Navdeep Brar, C. Braun, A Breach, M. Breitenfeldt, S Brenner, Brian Brettschneider, A Brewer, George J. Brewer, V Brindle, Elena Brioni, C. Titus Brown, Heather A. Brown, Louise Brown, R. H. Brown, Sarah Brown, Duncan L. Browne, K Bruce, Martina Brueckmann, Nigel J. Brunskill, Maria Bryant, Małgorzata M. Brzóska, Yang Bu, Cierra Buckman, Matthew J. Budoff, Michael Bullen, Andy Burke, Shane Burnette, Claire Burston, Martin Busch, John Bushnell, Susan Butler, Janine Büttner, Christopher D. Byrne, A Caamano, J Cadorna, Cesira Cafiero, Marianna P. Cagle, Jianwen Cai, Kátia da Silva Calabrese, Carla L. Calvi, Brian Camilleri, S Camp, Danielle Campbell, Ryan Campbell, Haiyan Cao, Irene Capelli, M Caple, Ben Caplin, A Cardone, J Carle, V Carnall, Maurizio Caroppo, Sue Carr, Gianni Carraro, Michael W. Carson, P. Casares, Carmen E. Castillo, Claudia Castro, B Caudill, Vladimir Cejka, Martina Ceseri, Leslie Cham, Alanna M. Chamberlain, Jonathan Chambers, CBT Chan, J.C. Chan, YC Chan, Emily Chang, Emily Chang, Terri Chant, T Chavagnon, P Chellamuthu, Fei Chen, Jing Chen, Peng Chen, TM Chen, Y Chen, Y Chen, Ching‐Yu Cheng, Hong Cheng, MC Cheng, David Z.I. Cherney, AK Cheung, CH Ching, Nihil Chitalia, Rushab Choksi, Charles Nnanna Chukwu, Kevin K. Chung, Giuseppe Cianciolo, L Cipressa, Sarah L. Clark, Harry S. Clarke, Robert W. Clarke, Samantha Clarke, B. T. Cleveland, Edward Cole, H Coles, L Condurache, Andrew Connor, Karen Convery, Angela Cooper, Nichola Cooper, Zara Cooper, Leslie Cooperman, Leah Cosgrove, Patricia Coutts, Allen W. Cowley, Rachel Craik, Guanglin Cui, T Cummins, Neera K. Dahl, Hui Dai, Lorraine H. Dajani, Anthony M. D’Amelio, E Damian, K Damianik, Laurence Danel, Curt J. Daniels, T. Daniels, S Darbeau, H Darius, Tanaji Dasgupta, J. Davies, Louise Davies, Andrew M. Davis, Joshua S. Davis, Laura Davis, R. Dayanandan, Sabriye Dayı, R Dayrell, Luca De Nicola, Subrata Debnath, Wissam Deeb, Stefan Degenhardt, K DeGoursey, Michael P. Delaney, Rajat Deo, Roger DeRaad, Vimal K. Derebail, Donovan A. Dev, M.A. Devaux, P Dhall, Gundeep Dhillon, J Dienes, Mirela Dobre, Eunice Doctolero, V Dodds, D. Domingo, Denise Donaldson, Peter Donaldson, C Donhauser, Vicki Donley, S Dorestin, S Dorey, Timothy Doulton, D Draganova, K Draxlbauer, F Driver, Huaan Du, F. Dubé, Tim Duck, Tabinda Dugal, Julianne Dugas, Hari Dukka, Hubert Dumann, W. B. Durham, Martin Dürsch, R Dykas, R Easow, E Eckrich, Gabriele Eden, Exodus Edmerson, Hellen McKinnon Edwards, LW Ee, Jun Eguchi, Yvonne Ehrl, Kerstin Eichstädt, William Eid, Bradley Eilerman, Yasuo Ejima, H Eldon, Timothy Ellam, L.J. Elliott, Richard T. Ellison, Jonathan Emberson, Riley Epp, Ayşe Er, M Espino-Obrero, Stephanie Estcourt, Luca Estienne, Gregory W. Evans, Julie Evans, Stephen Evans, Gianna Fabbri, M Fajardo-Moser, Colomba Falcone, Fereshteh Fani, P Faria-Shayler, Farahnaz Farnia, David Farrugia, Mirjam Fechter, D. Fellowes, F Feng, Cornelius James Fernandez, Pietro Manuel Ferraro, Andrew Field, Sameh Fikry, J Finch, Harrison T. Finn, Paola Fioretto, Richard S. Fish, Adiel Fleischer, D Fleming-Brown, Lucy Fletcher, Rostika Flora, C Foellinger, Nadia Edvige Foligno, Sylvain Forest, Zohreh Forghani, K Forsyth, Deidre Fottrell-Gould, Patricia Fox, A. Frankel, Donald Fraser, Robert C. Frazier, K. Frederick, Natalie Freking, Helen French, Anne Froment, Benjamin Fuchs, L Fuessl, Hideki Fujii, Akira Fujimoto, Ayaka Fujita, Ken‐ichi Fujita, Yasuko Fujita, Masafumi Fukagawa, Yusuke Fukao, Asuka Fukasawa, T Fuller, T Funayama, Erik Fung, Mariko Furukawa, Yusuke Furukawa, Masahide Furusho, Scott A. Gabel, J Gaidu, Sebastian Gaiser, Kelsey Gallo, Chris Galloway, Giovanni Gambaro, Chye Chung Gan, Chye Chung Gan, Ming Gao, K Garcia, M Garcia, Carlo Garofalo, Maureen J. Garrity, Amanda Garza, S Gasko, Mariana Gavrila, B Gebeyehu, A. Geddes, Giorgio Gentile, Arun George, Jyothis T. George, Loreto Gesualdo, Farid Ghalli, A Ghanem, Taneera Ghate, Sharang Ghavampour, Azmee Mohd Ghazi, Anca Gherman, U Giebeln-Hudnell, B. Gill, Sara Gillham, I Girakossyan, Matthias Girndt, Alfio Edoardo Giuffrida, Margaret Glenwright, T Glider, Rebecca Gloria, Deborah Glowski, BL Goh, CB Goh, Tomohito Gohda, Ronald Goldenberg, Rebecca F. Goldfaden, Colin E. Goldsmith, Benny Golson, Victoria Gonce, Qiuhong Gong, Bob Goodenough, Nick Goodwin, Michelle A. Goonasekera, A. S. Gordon, Jaymeson Gordon, Adwaita Gore, Hidemi Goto, Shinichi Goto, Shinichi Goto, D Gowen, Andrew A. Grace, James E. Graham, Giuseppe Grandaliano, Matthew P. Gray, JB Green, Tom Greene, Gemma K. 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Herzog, Sue Hewins, D Hewitt, Lisa Hichkad, S Higashi, C Higuchi, Christopher Hill, Lisa Hill, Michael Hill, Tatsuhito Himeno, Alfred Hing, Yosuke Hirakawa, Ken‐ichi Hirata, Yushi Hirota, Tomoko Hisatake, S Hitchcock, Alexander J. Hodakowski, William Hodge, Reed B. Hogan, U Hohenstatt, Bernd Hohenstein, Lai Seong Hooi, S Hope, Mark Hopley, Shunji HORIKAWA, Darya Hosein, Tetsuya Hosooka, L Hou, Wanyin Hou, L Howie, A. G. Howson, Mary Ann Hozak, Zay Htet, Xiaobin Hu, Ying Hu, Jianmin Huang, Nazmul Huda, Lisa Hudig, Amy Hudson, Christian Hugo, Robert Hull, L. Hume, W Hundei, Nicholas H. Hunt, Alan Hunter, Sinéad Hurley, Alison Hurst, Cary T. Hutchinson, Takanori Hyo, FH Ibrahim, Sara T. Ibrahim, N Ihana, Takaya Ikeda, Atsushi Imai, Rui Imamine, Aya Inamori, H Inazawa, J Ingell, Kenta Inomata, Y. Inukai, M Ioka, A Irtiza-Ali, Tamara Isakova, W Isari, M Iselt, Atsushi Ishiguro, Kazuyuki Ishihara, Toru Ishikawa, Takuji Ishimoto, Kiyonobu Ishizuka, R Ismail, Satoshi Itano, Hisao Ito, Kiyonori Ito, Ito M, Yukiko Ito, Shiho Iwagaitsu, Y Iwaita, Takashi Iwakura, Masahiro Iwamoto, Motoh Iwasa, Hitoshi Iwasaki, Shigeki Iwasaki, Kazuhiro Izumi, Kazuhiro Izumi, Takashi Izumi, SM Jaafar, Clare Jackson, Yves Jackson, G Jafari, Mahyar Jahangiriesmaili, Neemisha Jain, K. Jansson, Hiba Sabah Jasim, Lennox J. Jeffers, Alison Jenkins, M Jesky, Jorge Antonio Jesus Silva, D. Rohan Jeyarajah, Yan Jiang, Xue Jiao, Gema Jiménez, Bowen Jin, Qingchun Jin, J. Jochims, Beverly Johns, Cheryl K.H. Johnson, Timothy S. Johnson, Sagar Jolly, L Jones, L Jones, Steve Jones, Tara L. Jones, Virginia Jones, Matthew Joseph, Shirish Joshi, P. G. Judge, NoorNabi Junejo, Salahuddin Junus, Martin Kächele, Takashi Kadowaki, Hirokazu Kadoya, Hideyoshi Kaga, Hirayasu Kai, Hiroshi Kajio, Wiebke Kaluza-Schilling, Lydia Kamaruzaman, A Kamarzarian, Yoshio Kamimura, Hajime Kamiya, Charlotte Kamundi, Toshiki Kan, Yasuhiko Kanaguchi, Akishige Kanazawa, Eiichiro Kanda, Shinji Kanegae, Keizo Kaneko, Keizo Kaneko, H-Y Kang, T Kano, Mohammed Yousuf Karim, Dennis G. Karounos, W Karsan, Rina Kasagi, Naoki Kashihara, Hideki Katagiri, A Katanosaka, Akihiro Katayama, Michihito Katayama, Elliyyin Katiman, Katsuhito Kato, Masataka Kato, Noritoshi Kato, Sawako Kato, Takao Kato, Yuzuru Kato, Yoshiaki Katsuda, Tomoyuki Katsuno, Jessica Kaufeld, Yasemin Kavak, I Kawai, Maki Kawai, Maki Kawai, Akiko Kawase, S Kawashima, Amir Kazory, Janet Kearney, B Keith, Joanne Kellett, Scott D. Kelley, Michael H. Kershaw, Markus Ketteler, Q Khai, Quresh Khairullah, Hasnain Khandwala, KKL Khoo, Arif Khwaja, Kengo Kidokoro, Jan T. Kielstein, Michelle Kihara, Charlotte H. Kimber, S Kimura, Haruyasu Kinashi, Hugh Kingston, Masaru Kinomura, E Kinsella-Perks, Masashi Kitagawa, Maiko Kitajima, Shinji Kitamura, Arihiro Kiyosue, Maki Kiyota, F Klauser, Gerhard Klausmann, W Kmietschak, Karen Knapp, Cathryn Knight, A Knoppe, Carol Knott, Miki Kobayashi, R Kobayashi, Takaaki Kobayashi, Michael Koch, Satoru Kodama, Nobuyuki Kodani, Eisuke Kogure, Makoto Koizumi, H. Kojima, Takao Kojo, Nitin Kolhe, Hirotaka Komaba, Tatsuhiko Komiya, Hiroyuki Komori, SP Kon, Masahide Kondo, Masahide Kondo, William Kong, Masaaki Konishi, Keiji Kono, Masayuki Koshino, Tomoki Kosugi, B Kothapalli, Tomasz Kozłowski, Bernhard Kraemer, Annette Kraemer-Guth, J Krappe, Daniel Kraus, Charalampos Kriatselis, Charles Krieger, Patel Krish, Burkhard Krüger, KR Ku Md Razi, Ying Kuan, Shuji Kubota, Simone Kühn, Praveen Kumar, Shinji Kume, Ingrid Kummer, R Kumuji, A. Küpper, Takumi Kuramae, L Kurian, C Kuribayashi, Rijo Kurien, Emi Kuroda, Takeshi Kurose, Ana P. Kutschat, Naoki Kuwabara, Hirofumi Kuwata, Gaetano La Manna, M.G. Lacey, K. J. Lafferty, Paula LaFleur, Vesta Lai, Emily Laity, A Lambert, Martin Landray, Michel R. Langlois, F. Latif, E Latore, E Laundy, D Laurienti, Amy Lawson, M Lay, I. Leal, I Leal, AK Lee, J Lee, K. Lee, Rex H. Lee, S Lee, YY Lee, Y. Lee-Barkey, Niall Leonard, Giovanna Leoncini, C T Leong, Sarah Lerario, A Leslie, Adeera Levin, Andrew Lewington, J Li, Nailin Li, X Li, Yanmin Li, Lawrence Liberti, ME Liberti, Adrian Liew, Y-F. Liew, U Lilavivat, Soo Kun Lim, YS Lim, E Limon, Ho Lin, Eirini Lioudaki, H Liu, Jianjun Liu, Lei Liu, Qingyun Liu, Wenjun Liu, Xiangqiong Liu, Zhihong Liu, David Loader, H Lochhead, CL Loh, A. R. Lorimer, L Loudermilk, Jerome Loutan, CK Low, CL Low, YM Low, Z Lozon, Yanqin Lu, Donata Lucci, Ute Ludwig, N Luker, Donald D. Lund, Robert A. Lustig, Stephen Lyle, Cameron Macdonald, Iain C. Macdougall, Rosario Machicado, Derek Maclean, Patrick MacLeod, A Madera, F. Madore, Keiko Maeda, Hiroshi Maegawa, S Maeno, Marion Mafham, James S. Magee, Aldo P. Maggioni, DY Mah, Vahid Pirhajati Mahabadi, Masayuki Maiguma, Y Makita, Gail Makos, Licínio Manco, Roberto Mangiacapra, James L. Manley, Peter Mann, Satoshi Mano, G Marcotte, John M. Maris, Patrick B. Mark, Silke Markau, Miroslav Marković, Carol Marshall, María Martin, Cristina Martínez, Socorro Piñones Martínez, G Martins, Ken Maruyama, Shoichi Maruyama, Kayleigh Marx, Amy Maselli, Agnes Masengu, A Maskill, Shoichi Masumoto, Kosuke Masutani, Mayumi Matsumoto, T Matsunaga, N. Matsuoka, M. Matsushita, Michael Matthews, S Matthias, Е. В. Матвиенко, Mathew Maurer, Patrick H. Maxwell, KJ Mayne, N Mazlan, SA Mazlan, A Mbuyisa, Kieran McCafferty, Frank McCarroll, Thomas McCarthy, C McClary-Wright, K McCray, Philip McDermott, Carrie R. McDonald, Renee McDougall, E McHaffie, K McIntosh, Todd O. McKinley, Stephen McLaughlin, N.R. McLean, Lynne McNeil, A Measor, James Meek, Anurag Mehta, Rupal Mehta, M. Melandri, Paolo Mené, Tian Meng, Jan Menne, K.A. Merritt, Sandra Merscher, C Meshykhi, Piergiorgio Messa, Laura Messinger, N. Miftari, Rachel K. Miller, Y E Miller, Eve Miller‐Hodges, Makiko Minatoguchi, M Miners, Roberto Minutolo, Takashi Mita, Y. Miura, Makoto Miyaji, Satoshi Miyamoto, Takeshi Miyatsuka, Megumi Miyazaki, Itsuko Miyazawa, Ryoji Mizumachi, Masashi Mizuno, Scott D. Moffat, FS Mohamad Nor, SN Mohamad Zaini, FA Mohamed Affandi, Cynthia Mohandas, Rozita Mohd, NA Mohd Fauzi, Nissan Bin Sharif, Yusniza Yusoff, Louise Moist, A Moncada, Mahmoud Montasser, Andrew M. Moon, César A. Moran, Neal Morgan, James P. Moriarty, G Morig, Hiroshi Morinaga, Katsutaro Morino, T. Morisaki, Y Morishita, S Morlok, Alison Morris, F Morris, Sadek Mostafa, Y Mostefai, Mikio Motegi, N Motherwell, Davide Motta, Amy K. Mottl, R Moys, Sahar V. Mozaffari, James Muir, Jeffrey Mulhern, Stephen P. Mulligan, Yasuhisa Munakata, Christine Murakami, Masanori Murakoshi, Aleksandra Murawska, Kieran C. Murphy, Lee Murphy, Susan Murray, Hugh Murtagh, MA Musa, Lily Mushahar, Reem A. Mustafa, Ruslinda Mustafar, Manabu Muto, Evelyn Nadar, R Nagano, Toshihiko Nagasawa, Eiichi Nagashima, Hajime Nagasu, S Nagelberg, Harish Nair, Yoshihisa Nakagawa, M Nakahara, Jiro Nakamura, Ryô Nakamura, Tomonobu Nakamura, M Nakaoka, Eitaro Nakashima, Jun Nakata, M Nakata, Sakura Nakatani, Atsuko Nakatsuka, Yui Nakayama, Georges Nakhoul, M Nangaku, G Naverrete, A Navivala, I Nazeer, Lavinia Negrea, Chidambaram Nethaji, Erik T. Newman, SYA Ng, TJ Ng, LLS Ngu, T Nimbkar, Hiroshi Nishi, Masahiro Nishi, Shinichi Nishi, Yoko Nishida, Akira Nishiyama, Jingbo Niu, Ping Niu, Alessandro Nobili, Nozomi Nohara, Ikuko Nojima, Jerry P. Nolan, H Nosseir, Masahiro Nozawa, Miles A. 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Phillips, Marion Phipps, G Piccinni, T Pickett, S. Pickworth, M. Piemontese, Daniel Pinto, Joyce M. Piper, J Plummer-Morgan, Diana Poehler, Lucio Polese, Valentina Vultaggio-Poma, R Pontremoli, Anna Postal, C Pötz, Albert Power, N Pradhan, Ravi Ranjan Pradhan, David Preiss, E Preiss, Kenzie L. Preston, Natalie Prib, Lori Lyn Price, Carlo Provenzano, C Pugay, Rafael Pulido, Franz Josef Putz, Y. Qiao, R. Quartagno, M Quashie-Akponeware, Ria Rabara, Rémi Rabasa‐Lhoret, Divya M. Radhakrishnan, Milford Radley, R Raff, Shayani Raguwaran, Frederic F. Rahbari-Oskoui, Mahboob Rahman, Kartini Rahmat, S Ramadoss, S Ramanaidu, S Ramasamy, R. Ramli, S. Ramli, Tasha Ramsey, Alastair J. Rankin, Arash Rashidi, Laure Raymond, WAFA Razali, Kerry Read, H Reiner, A Reisler, Christina Reith, Jordan B. Renner, Bianka Rettenmaier, Leah Richmond, Dolores Rijos, Rodolfo Rivera, Vanessa Rivers, Hannah Robinson, Michael V. Rocco, I Rodriguez-Bachiller, R Rodriquez, Charles Roesch, Johannes Roesch, John Rogers, M Rohnstock, S Rolfsmeier, Mary J. Roman, A Romo, Alberto Rosati, Sarah Rosenberg, Talisa Ross, X Rossello, M. Roura, Martine F. Roussel, Sergio Rovner, Subarna Roy, Sally Rucker, Lars Christian Rump, Maria Grazia Ruocco, Scott Ruse, Francesco Paolo Russo, María Luisa Russo, Mary Ryder, A Sabarai, Chiara Saccà, Richard Sachson, Emma Sadler, NS Safiee, Mandeep Sahani, A Saillant, J. Saini, Chie Saito, Shingo Saito, Kazuhiko Sakaguchi, Masahiro Sakai, Hotimah Masdan Salim, Chiara Salviani, E Sammons, Amanda K. Sampson, Fernand Samson, Peter Sandercock, Shariff Sanguila, Gennaro Santorelli, Domenico Santoro, Nagaraju Sarabu, T Saram, Rebecca J. Sardell, Hisashi Sasajima, Tsutomu Sasaki, Scott G. Satko, Akemi Sato, Daisuke Sato, Hiroshi Satō, Hiroshi Sato, Jussara Leiko Sato, Tosiya Sato, Yasunori Sato, Mamoru Satoh, Koji Sawada, Moritz Schanz, F Scheidemantel, Mara Schemmelmann, Elke Schettler, Volker Schettler, GR Schlieper, Caroline Schmidt, Georg Schmidt, U Schmidt, Hans-Jürgen Schmidt-Gürtler, M Schmude, A Schneider, Ione Jayce Ceola Schneider, C Schneider-Danwitz, Michael Schömig, T. K. Schramm, A Schreiber, Severin Schricker, Bernd Schröppel, Lena Schulte‐Kemna, Eike C. Schulz, Beate Schumacher, Antonia Schuster, A. Schwab, Francesco Scolari, Andrew M. Scott, Werner Seeger, Werner Seeger, Mark S. Segal, Lena Seifert, Michael Seifert, Masatoshi Sekiya, R Sellars, MR Seman, Sanjiv J. Shah, Sanjiv J. Shah, L Shainberg, Mayooran Shanmuganathan, Fengmin Shao, Kumar Sharma, Claire C. Sharpe, M Sheikh-Ali, J Sheldon, Catriona Shenton, Amanda C. 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BACKGROUND: Sodium-glucose co-transporter-2 (SGLT2) inhibitors reduce progression of chronic kidney disease and the risk of cardiovascular morbidity and mortality in a wide range of patients. However, their effects on kidney disease progression in some patients with chronic kidney disease are unclear because few clinical kidney outcomes occurred among such patients in the completed trials. In particular, some guidelines stratify their level of recommendation about who should be treated with SGLT2 inhibitors based on diabetes status and albuminuria. We aimed to assess the effects of empagliflozin on progression of chronic kidney disease both overall and among specific types of participants in the EMPA-KIDNEY trial. METHODS: with a urinary albumin-to-creatinine ratio (uACR) of 200 mg/g or higher. We explored the effects of 10 mg oral empagliflozin once daily versus placebo on the annualised rate of change in estimated glomerular filtration rate (eGFR slope), a tertiary outcome. We studied the acute slope (from randomisation to 2 months) and chronic slope (from 2 months onwards) separately, using shared parameter models to estimate the latter. Analyses were done in all randomly assigned participants by intention to treat. EMPA-KIDNEY is registered at ClinicalTrials.gov, NCT03594110. FINDINGS: <0·0001). INTERPRETATION: Empagliflozin slowed the rate of progression of chronic kidney disease among all types of participant in the EMPA-KIDNEY trial, including those with little albuminuria. Albuminuria alone should not be used to determine whether to treat with an SGLT2 inhibitor. FUNDING: Boehringer Ingelheim and Eli Lilly.