Low expression of hexokinase-2 is associated with false-negative FDG–positron emission tomography in multiple myeloma

著者: Leo Rasche, Edgardo Angtuaco, James E. McDonald, Amy Buros, Caleb Stein, Charlotte Pawlyn, Sharmilan Thanendrarajan, Carolina Schinke, Rohan Samant, Shmuel Yaccoby, Brian A. Walker, Joshua Epstein, Maurizio Zangari, Frits van Rhee, Tobias Meißner, Hartmut Goldschmidt, Kari Hemminki, Richard S. Houlston, Bart Barlogie, Faith E. Davies, Gareth J. Morgan, Niels Weinhold - Blood 2017 被引用: 248

< .001) which provides a mechanistic explanation for this feature. In conclusion, we demonstrate a relevant number of patients with FDG-PET false-negative MM and a strong association between hexokinase-2 expression and this negativity: a finding which may also be relevant for clinical imaging of other hematological cancers.